Algos researchers have published extensive pain research. Following is a listing of our publications. With over 50 papers and posters collectively to our name, we have the intellectual horse power to support your research initiatives.

Algos researchers contributing papers include; James D. Pominis, PhD, Susan Gotshall, Cheryl L. Marker, PhD, and David M. Cain, PhD

James D. Pomonis, PhD – Publications

Levin, ME, Jin, JG, Ji, R-R, Tong, J, Pomonis, JD Lavery, DJ, Miller, SW, and Chiang, LW. (2008) Complement activation in the peripheral nervous system following the spinal nerve ligation model of neuropathic pain. Pain 137(1):182-201.

Pomonis, JD and Shurman JR. (2007) Uses of TENS for pain management. Practical Pain Management 7(6):46-51.

Ilyin, VI, Pomonis, JD, Whiteside, GT, Harrison, JE, Pearson, MS, Mark, L, Turchin, PI, Gottshall, SL, Carter, RB, Nguyen, P, Hogenkamp, DJ, Olanrewaju, S, Benjamin, E, and Woodward, RM (2006) Pharmacology of 2-[4-(4-chloro-2-fluorophenoxy) phenyl]-pyrimidine-4-carboxamide (PPPA): a potent, broad-spectrum state- dependent sodium channel blocker for treating pain states. The Journal of Pharmacology and Experimental Therapetuics 318(3):1083-93.

Pomonis, JD, Boulet, JM, Gottshall, SL, Phillips, S, Sellers, R, Bunton, T, and Walker, K. (2005) Development and characterization of a rat model of osteoarthritis pain. Pain, 114(3): 339-346.

Whiteside, GT, Woods, ME, Pearson, MS, Pomonis, JD, Turchin, PI, and Walker, K. (2005) Ablation of a population of neurons in the dorsal horn of the spinal cord is insufficient to induce sprouting of touch responsive myelinated afferents into the innervation territory of pain sensitive unmyelinated afferents. Medical Hypotheses and Research 2: 275-282.

Whiteside, GT, Harrison, JE, Pearson, MS, Chen, Z, Rotshteyn, Y, Turchin, PI, Pomonis, JD, Mark, L, Walker, K and Brogle, KC. (2004) DiPOA ([8-(3,3-diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triaza-spiro[4,5]dec-3-yl]acetic acid), a novel, systemically-available and peripherally restricted mu opioid agonist with anti-hyperalgesic activity: 2. In vivo pharmacological characterization in the rat. The Journal of Pharmacology and Experimental Therapetuics, 310(2): 793-799.

Peters, CM, Lindsay, TH, Pomonis, JD, Luger, NM, Ghilardi, JR, Sevcik, MA, and Mantyh, PW. (2004) Endothelin and the tumorigenic component of bone cancer pain. Neuroscience, 126(4): 1043-1052.

Levine, AS, Olszewski, PK, Mullett, MA, Pomonis, JD, Grace, MK, Kotz, CM, and Billington, CJ. (2004) Intra-amygdalar injection of DAMGO: effects on cFos levels in brain sites associated with feeding behavior. Brain Research 1015(1-2):9-14.

Pomonis, JD, Harrison, JE, Mark, L, Bristol, DR, Valenzano, KJ, and Walker, K (2003) N-(4-tertiarybutylphenyl)-4-(3-chlorophyridin-2-yl)tetrahydropyrazine-1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: II. In vivo characterization in rat models of inflammatory and neuropathic pain. The Journal of Pharmacology and Experimental Therapeutics, 306(1): 387-93.

Egnaczyk, GF, Pomonis, JD, Schmidt, JA, Rogers, SD, Peters, C, Ghilardi, JR, Mantyh, PW, and Maggio, JE (2003) Proteomic analysis of the reactive phenotype of astrocytes following endothelin-1 exposure. Proteomics 3(5): 689-698.

Peters, CM, Rogers, SD, Pomonis, JD, Egnaczyk, GF, Keyser, CP, Schmidt, JA, Ghilardi, JR, Maggio, JE, and Mantyh, PW (2003) Endothelin receptor expression in the normal and injured spinal cord: Potential involvement in injury-induced ischemia and gliosis. Experimental Neurology 180(1): 1-13.

Rogers, SD, Peters, CM, Pomonis, JD, Hagiwara, H, Ghilardi, JR, and Mantyh, PW (2003) Endothelin B receptors are expressed by astrocytes and regulate astrocyte hypertrophy in the normal and injured CNS. Glia 41(2): 180-190.

Luger, NM, Sabino, MA, Schwei, MJ, Mach, DB, Pomonis, JD, Keyser, CP, Rathbun, M, Clohisy, DR, Honore, P, Yaksh, TL, and Mantyh, PW (2002) Efficacy of systemic morphine suggests a fundamental difference in the mechanisms that generate bone cancer pain vs. inflammatory pain. Pain 99(3): 397-406.

Mach, DB, Rogers, SD, Sabino, MC, Luger, NM, Schwei, MJ, Pomonis, JD, Keyser, CP, Clohisy, DR, Adams, DJ, O’Leary, P, and Mantyh, PW (2002) Origins of skeletal pain: Sensory and sympathetic innervation of the mouse femur. Neuroscience 113(1): 155-166.

Pomonis, JD, Rogers, SD, Peters, CM, Ghilardi, JR, and Mantyh, PW (2001) Expression and localization of endothelin receptors: Implications for the involvement of peripheral glia in nociception. The Journal of Neuroscience 21(3): 999-1006.

Pomonis, JD, Jewett, DC, Kotz, CM, Briggs, JE, Billington, CJ, and Levine, AS (2000) Sucrose consumption increases naloxone-induced cFos immunoreactivity in limbic forebrain. American Journal of Physiology (Regulatory, Integrative and Comparative Physiology) 278(3): R712-R719.

Cleary, JP, O’Hare, E, Pomonis, JD, Dittel, PL, Hofmeister, JJ, Friz,MM, Billington, CJ, and Levine, AS (1999) Discriminative stimulus effects of morphine: central versus peripheral training. Brain Research 847(1): 26-31.

Kotz, CM, Briggs, JE, Pomonis, JD, Grace, MK, Levine, AS, andBillington, CJ (1998) Neural site of leptin influence on neuropeptide Y signaling pathways altering feeding and uncoupling protein. American Journal of Physiology (Regulatory, Integrative and Comparative Physiology 275(2 Part 2): R478-R484.

O’Hare, E, Cleary, J, Weldon, DT, Pomonis, JD, Billington, CJ, and Levine, AS (1998) Intrahypothalamic discriminative stimulus effects of neuropeptide Y. Pharmacology, Biochemistry, and Behavior 59(2): 375-378.

Pomonis, JD, Levine, AS, and Billington, CJ (1997) Interaction of the hypothalamic paraventricular nucleus and central nucleus of the amygdala in naloxone blockade of neuropeptide Y-induced feeding revealed by c-fos expression. The Journal of Neuroscience 17(13): 5175-5182.

Pomonis, JD, Billington, CJ, and Levine, AS (1996) Orphanin FQ, agonist of orphan opioid recepotr ORL-1, stimulates feeding in rats. Neuroreport 8(1): 269-371.

Valenzano, KJ, Pomonis, JD, and Walker, K. (2005) TRPV1 antagonists and chronic pain. In: Turning Up the Heat on Pain: TRPV1 Receptors in Pain and Inflammation. Malmberg, AB and Bley, KR, eds. Basel: Birkhauser Verlag.

Pomonis, JD (2006) Rat Models of Osteoarthritis. In: The Encyclopedic Reference of Pain. Schmidt, RF, and Willis, WD, eds. Heidelberg, Springer-Verlag.

Susan Gottshall – Publications

Ilyin, V.I., Pomonis, J.D., Whiteside, G.T., Harrison, J.E., Pearson, M.S., Mark, L., Turchin, P.I., Gottshall, S., Carter, R.B., Nguyen, P., Hogenkamp, D.J., Olanrewaju, S., Benjamin, E. and Woodward R.M. (2006) Pharmacology of 2-{4-(4-chloro-2-fluorophenoxy) phenyl]-pyrimidine-4-carboxamide: a potent, broad spectrum state-dependent sodium channel blocker for treating pain states. The Journal of Pharmacology and Experimental Therapeutics, 318:1083-1093.

Whiteside, G.T., Gottshall, S.L., Boulet, J.M., Chaffer, S.M., Harrison, J.E., Pearson, M.S., Turchin, P.I., Mark, L., Garrison, A.E. and Valenzano, K.E. (2005) A role for cannabinoid recptors, but not endogenous opioids, in the antinociceptive activity of the CB2-Selective agonist, GW405833. European Journal of Pharmacology, 528:65-72.

Valenzano, K.J., Tafesse L., Lee, G., Harrison J.E., Boulet, J.M., Gottshall, S.L., Mark, L., Pearson M.S., Miller, W., Shan, S., Rabadi, L., Rotshteyn, Y., Chaffer, S.M., Turchin, P.I., Elsmore, D.A., Toth, M., Koetzner, L. and Whiteside G.T. (2005) Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia and catalepsy. Neuropharmacology, 48:658-672.

Tuthill, P.A., Seida, P.R., Barker, W., Cassel, J.A., Belanger, S., DeHaven, R.N., Koblish, M., Gottshall, S.L., Little, P.J., DeHaven-Hudkins, D.L. and Dolle, R.E. (2004)Azepinone as a conformational constraint in the design of kappa receptor agonists. Bioorganic and Medicinal Chemistry Letters 14:5693-5697.

Pomonis, JD, Boulet, JM, Gottshall, SL, Phillips, S, Sellers, R, Bunton, T, and Walker, K. (2005) Development and characterization of a rat model of osteoarthritis pain. Pain, 114(3): 339-346.

Whiteside, G.T., Harrison J., Boulet, J., Mark, L., Pearson, M., Gottshall, S. and Walker K. (2004) Pharmacological characterization of a rat model of incisional pain. British Journal of Phamacology 141:85-91.

Kumar V., Marella M.A., Cortes-Burgos L., Chang A.C., Cassel J.A., Daubert J.D., DeHaven R.N., DeHaven-Hudkins D.L., Gottshall S.L., Mansson E., and Maycock A.L. (2000) Arylacetamides as peripherally restricted kappa opioid receptor agonists. Bioorganic and Medicinal Chemistry Letters. 10:2567-2570.

Liu W.J., Gottshall S.L. and Hansen P.J. (1997) Increased expression of cell surface markers on endometrial γ/δ T-cell receptor+ intraepithelial lymphocytes induced by the local presence of the sheep conceptus. American Journal of Reproductive Immunology 37:199-205.

Davidson J.A., Wright J.D., Archbald L.F., Klapstein E., Gottshall S.L. and Hansen P.J. (1996) Effect of induced pyometra on luteal lifespan and uterine fluid concentrations of prostaglandins and interferons. Theriogenology. 45:459-470.

Gottshall S.L. and Hansen P.J. (1994) Enhancement of mitogen-induced lymphocyte proliferation in sheep. Journal of Veterinary Medicine B 41:541-548.

Gottshall S.L. and Hansen P.J. (1992) Regulation of leucocyte subpopulations in the sheep endometrium by progesterone. Immunology. 76:636-641.

Cheryl L. Marker, PhD – Publications

Smith SB, Marker CL, Perry C, Liao G, Sotocinal SG, Austin JS, Melmed K, Clark JD, Peltz G, Wickman K, Mogil JS (2008) Quantitative trait locus and computational mapping identifies Kcnj9 (GIRK3) as a candidate gene affecting analgesia from multiple drug classes. Pharmacogenetics and Genomics 18(3):231-41.

Marker CL, Lujan R, Colón J, Wickman K (2006) Distinct populations of spinal cord lamina II interneurons expressing G protein-gated potassium channels. The Journal of Neuroscience 26(47):12251-12259.

Kulik A, Fukazawa Y, Guetg N, Kasugai Y, Marker CL, Rigato F, Bettler B, Wickman K, Frotscher M, Shigemoto R (2006) Compartment-dependent colocalization of Kir3.2-containing K+ channels and GABAB receptors in hippocampal pyramidal cells. The Journal of Neuroscience 26(16):4289-4297.

Marker CL, Loh HH, Lujan R, Wickman K (2005) Spinal G protein-gated potassium channels mediate the analgesia evoked by high doses of mu and delta opioid receptor agonists. The Journal of Neuroscience. 25(14): 3551-3559.

Marker CL, Stoffel M, Wickman K. (2004) Spinal G protein-gated K+ channels formed by GIRK1 and GIRK2 subunits modulate thermal nociception and contribute to morphine analgesia. The Journal of Neuroscience 24(11):2806-2812.

Bettahi I, Marker CL, Roman MI, Wickman K (2002) Contribution of the Kir3.1 subunit to the muscarinic-gated atrial potassium channel IKACh. Journal of Biological Chemistry 277(50):48282-48288.

Marker CL, Cintora SC, Roman MI, Stoffel M, Wickman K (2002) Hyperalgesia and blunted morphine analgesia in G-protein-gated potassium channel subunit knockout mice. Neuroreport 13(18):2509-2513.

Torrecilla M, Marker CL, Cintora SC, Stoffel M, Williams JT, Wickman K (2002) G protein-gated potassium channels containing Kir3.2 and Kir3.3 subunits mediate the acute inhibitory effects of opioids on locus ceruleus neurons. The Journal of Neuroscience 22(11):4328-4344.

Hamamoto D, Khasabov S, Cain D, Simone D. (2008) Tumor-evoked Sensitization of C Nociceptors: A Role for Endothelin. Journal of Neurophysiogy 100: 2300-2311.

Gilchrist LS, Cain DM, Harding-Ross C. Kov AN, Wendelschafer-Crabb G, Kennedy WR, Simone DA. (2005) Re-organization of P2X(3) receptor localization on epidermal nerve fibers in a murine model of cancer pain. Brain Researc. 1044(2):197-205

Cain, DM, Wacnik PW, Turner M, Wendelschafer-Crabb G, Kennedy WR, Wilcox GL, Simone DA (2001) Functional interactions between tumor and peripheral nerve: changes in excitability and morphology of primary afferent fibers in a murine model of cancer pain. The Journal of Neuroscience 21(23):9367-9376.

Cain, DM, Khasabov SG, and Simone DA. (2001) Response Properties of Mechanoreceptors and Nociceptors in Mouse Glabrous Skin: An In Vivo Study. Journal of Neurophysiology 85:1561-1574.

Cain DM, Wacnik PW, Simone DA. (2001) Animal models of cancer pain may reveal novel approaches to palliative care. Pain 91(1-2):1-4.

Cain DM, Wacnik PW, Eikmeier L, Beitz A, Wilcox GL, Simone DA. (2001) Functional Interactions between Tumor and Peripheral Nerve in a Model of Cancer Pain in the Mouse. Pain Medicine 2(1):15-23.

Khasabov SG, Cain DM, Thong Y, Mantyh, PW., Simone DA. (2001) Enhanced responses of spinal dorsal horn neurons to heat and cold stimuli following mild freeze injury to the skin. Journal of Neurophysiology 86:986-996.

Cain, D. and Jen, P.H.-S. (1999) The effect of sound direction on frequency tuning in mouse inferior collicular neurons. Chinese Journal of Physiology 42(1):1-8.

Chen, Q.-C., Cain, D., Jen, P.H.-S. (1997) Sound pressure transformation at the pinna of Mus domesticus. Acta Otolaryngology (Stockh), Suppl 532:141-143.

Chen, Q.-C., Cain, D., Jen, P.H.-S. (1995) Sound pressure transformation at the pinna of Mus domesticus. Journal of Experimental Biology 198:2007-2023.